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Dr. Vakhtang Barbakadze

Dr. Vakhtang Barbakadze

Professor Tbilisi State Medical University Georgia

Title: Biopolymer of Medicinal Plants with Anticancer Efficacy

Biography

Biography: Dr. Vakhtang Barbakadze

Abstract

dihydroxyphenyl  and  carboxyl  groups  are  regular  substituents  at  two  carbon   atoms  in the  chain.  The   repeating  unit  of  this   regular  polymer  is  3-(3,4-dihydroxyphenyl)glyceric acid residue. This compound   is  a  first representative  of  a  new  class  of  natural  polyethers. Then  the racemic  monomer  2,3-dihydroxy-3-(3,4-dihydroxyphenyl)propionic acid (DDPPA)  and  its virtually  pure  enantiomers  (+)-(2R,3S)-2,3-dihydroxy-3-(3,4-dihydroxyphenyl)propionic  acid  and (-)-(2S,3R)-2,3-dihydroxy-3-(3,4-dihydroxyphenyl)propionic acid  were  synthesized  for  the  first  time  via  Sharpless  asymmetric  dihydroxylation   of  trans-caffeic  acid  derivatives  using  an osmium  catalyst, a stoichiometric oxidant N-methylmorpholine-N-oxide and enantiocomplementary catalysts  cinchona  alkaloid  derivatives  (DHQ)2-PHAL  and  (DHQD)2-PHA as  chiral auxiliaries. PDPGA  has  wide  spectrum  of  biological activity: anticomplementary,  antioxidant,  antiinflammatory  properties,  burn  and   wound  healing  effect.  PDPGA and DDPPA  exerted  anti-cancer efficacy  in vitro  and  in vivo  against  androgen-dependent  and androgen -independent  human  prostate cancer (PCA) cells  via  targeting  androgen  receptor,  cell  cycle  arrest  and  apoptosis  without  any  toxicity, together  with  a strong  decrease  in  prostate  specific antigen  level in plasma. However, our  results  showed  that anticancer efficacy of  PDPGA is more effective compared to its synthetic  monomer. Overall, this study identifies  PDPGA as a potent agent against PCA  without any toxicity, and  supports  its clinical application