7^th World Congress on Biopolymers and Polymer Chemistry June 4-6, 2018 Osaka, Japan

Biography:

MSc-1977 (in Applied Physics), PhD (in Physics and Mathematics)-1980, DSc (Habilitation, (in Physics and Mathematics)-1989. Affiliations: The Institute for Problems in Mechanics of the Academy of Sciences of the USSR, Moscow (1977-1990); Professor at The Technion-Israel Institute of Technology (1990-2006; Eduard Pestel Chair Professor in Mechanical Engineering at The Technion in 1999-2006); Distinguished Professor at The University of Illinois at Chicago, USA (2006-present); Fellow of the American Physical Society. Prof. Yarin is the author of 4 books, 12 book chapters, 310 research papers, and 6 patents. Prof. Yarin was the Fellow of the Rashi Foundation, The Israel Academy of Sciences and Humanities, and was awarded Gutwirth Award, Hershel Rich Prize and Prize for Technological Development for Defense against Terror of the American-Technion Society. He is one of the three co-Editors of “Springer Handbook of Experimental Fluid Mechanics”, 2007, and the Associate Editor of the journal “Experiments in Fluids”.

Abstract:

Biography:

1978 and 1999 has completed his Ph.D and D.Sci. at the ages of 33 and 54 years from Zelinsky Instiute of Organic Chemistry, Moscow, Russia and Durmishidze Institute of Biochemistry and Biotechnology, Tbilisi, Georgia, respectively. 2006 up to date he is the head of laboratory of plant biopolymers at the Tbilisi State Medical University Institute of Pharmacochemistry. 1996 and 2002 he has been a visiting scientist at Utrecht University (faculty of pharmacy), The Netherlands, by University Scholarship and The Netherlands organization for scientific research (NWO) Scholarship Scientific Program, respectively. He has published more than 80 papers in reputed journals.

Abstract:

dihydroxyphenyl  and  carboxyl  groups  are  regular  substituents  at  two  carbon   atoms  in the  chain.  The   repeating  unit  of  this   regular  polymer  is  3-(3,4-dihydroxyphenyl)glyceric acid residue. This compound   is  a  first representative  of  a  new  class  of  natural  polyethers. Then  the racemic  monomer  2,3-dihydroxy-3-(3,4-dihydroxyphenyl)propionic acid (DDPPA)  and  its virtually  pure  enantiomers  (+)-(2R,3S)-2,3-dihydroxy-3-(3,4-dihydroxyphenyl)propionic  acid  and (-)-(2S,3R)-2,3-dihydroxy-3-(3,4-dihydroxyphenyl)propionic acid  were  synthesized  for  the  first  time  via  Sharpless  asymmetric  dihydroxylation   of  trans-caffeic  acid  derivatives  using  an osmium  catalyst, a stoichiometric oxidant N-methylmorpholine-N-oxide and enantiocomplementary catalysts  cinchona  alkaloid  derivatives  (DHQ)2-PHAL  and  (DHQD)2-PHA as  chiral auxiliaries. PDPGA  has  wide  spectrum  of  biological activity: anticomplementary,  antioxidant,  antiinflammatory  properties,  burn  and   wound  healing  effect.  PDPGA and DDPPA  exerted  anti-cancer efficacy  in vitro  and  in vivo  against  androgen-dependent  and androgen -independent  human  prostate cancer (PCA) cells  via  targeting  androgen  receptor,  cell  cycle  arrest  and  apoptosis  without  any  toxicity, together  with  a strong  decrease  in  prostate  specific antigen  level in plasma. However, our  results  showed  that anticancer efficacy of  PDPGA is more effective compared to its synthetic  monomer. Overall, this study identifies  PDPGA as a potent agent against PCA  without any toxicity, and  supports  its clinical application

Biography:

Prof. Vimal Katiyar is a Coordinator of Centre of Excellence for Sustainable Polymers, in the department of Chemical Engineering at IIT Guwahati, India. The centre of excellence on sustainable polymers is focusing on development of cost-effective, bio-based and biodegradable plastic products and related technologies using various feedstock including biopolymers such as cellulose, chitosan, proteins, various protein grafted polysaccharides. He has published more than seventy peer reviewed publications in highly reputed journals such as American Chemical Society and Nature publishing journals.  He has supervised seven PhD students and more than twenty students are pursuing PhD under his supervision. His recently featured book entitled as ‘Bio-based Plastics for Food Packaging Applications’ is published by Smithers Rapra, UK. He is a co-inventor of numerous granted patents in various countries including India, USA, Canada, Europe, Japan, etc. His research group has received multiple national and international innovation awards in the development of bio-based polymeric products, nanobiomaterials, and related technologies.

Abstract:

This presentation highlights the use of available bio-resources for value added sustainable polymeric products for Engineering, Commodity and Biomadical Applications. Biopolymers can be extracted from renewable feedstock such as plants, marine animals, insects, etc. It is noteworthy to mention that so far biopolymers extracted from these sources have limited applications in large scale plastic production. Among the available bio-based synthetic plastics, polylactic acid (PLA) has made its own place due to its biodegradability and potential to replace conventional fossil based plastics. It is noteworthy to mention that properties such as melting point, heat deflection temperature and gas barrier properties limits its use in high temperature commodity and engineering applications. However, these limitations can be overcome by developing new class of high molecular weight stereocomplex PLA (sc-PLA). In this context, we have synthesized sc-PLA and its sc-PLA-bionanocomposites by using different biobased nanofillers which includes cellulose nanocrystals, silk nanocrystals, modified chitosan, etc. The GPC analysis reveals that the synthesized stereo-complex based bionanocomposites have molecular weight higher than 100 kDa. The formation of stereocomplex crystallites is confirmed by the XRD analysis. Melting point of the composite is increased even higher than 225°C which suggests the formation of stereocomplex crystallites and the crystallization temperature is enhanced upto ~155°C at nanofillers loading of 5 wt%. Due to the presence of various bionanofillers, ultimate tensile strength is enhanced significantly. Based on the studies, it can be concluded that bionanofillers are good candidates for enhancing the stereocomplexation in the PLA. In this talk, fabrication strategies for synthesis of stereocomplex-PLA-bionanocomposites and evaluation of their properties along with possible applications will be discussed. This talk will also include the processing of these bionanocomposites into caste films and injection molded products for biomadical applications.