Biopolymers and Biomaterials

Biopolymers in Drug Delivery Systems

Biopolymers are emerging as key players in the field of drug delivery systems (DDS), offering numerous advantages due to their biocompatibility, biodegradability, and versatility. These natural or synthetic polymers, derived from biological sources such as plants, animals, or microorganisms, are increasingly being used to improve the efficiency and effectiveness of drug delivery. Biopolymers play a crucial role in protecting active pharmaceutical ingredients (APIs), controlling their release, and targeting specific sites within the body, making them a powerful tool for enhancing therapeutic outcomes. One of the primary benefits of biopolymers in drug delivery is their ability to improve the stability and solubility of poorly water-soluble drugs. Through encapsulation in biopolymer matrices, drugs are protected from degradation, leading to enhanced bioavailability. Biopolymers such as alginate, chitosan, and poly(lactic-co-glycolic acid) (PLGA) are widely utilized for the development of nanoparticles, microparticles, and hydrogels for drug encapsulation, facilitating controlled and sustained release over extended periods. Another advantage of biopolymers in DDS is their potential for site-specific drug delivery. By modifying biopolymers with targeting ligands, drugs can be delivered to specific tissues or cells, enhancing therapeutic efficacy and minimizing side effects. For example, biopolymer-based nanoparticles can be designed to target cancer cells, delivering chemotherapeutic agents directly to the tumor site, thereby reducing toxicity to healthy tissues.